1/11/2024 0 Comments Significance of caffeine structure![]() ![]() It may, thus, attenuate the increase in sleep pressure during wakefulness 8 and lead to delayed sleep initiation and more superficial sleep 9. Caffeine is an adenosine receptor antagonist, which blocks the A 1 and A 2A adenosine receptors in the central nervous system 1. Sleep homeostasis describes the increase in sleep pressure during time awake and its dissipation during the following sleep episode 6, which has been suggested to be related to rising and decreasing concentrations of adenosine 7. The sleep disrupting effects of caffeine are mainly attributed to its influence on the homeostatic component of sleep-wake regulation. While caffeine is frequently used to counteract sleepiness and boost performance 3, its consumption is commonly avoided in the evening 4, 5 to prevent adverse consequences on nocturnal sleep 3. The reduced EEG power density in the sigma range might represent early signs of overnight withdrawal from the continuous presence of the stimulant during the day.Ĭaffeine is the most popular psychoactive substance in the world 1, consumed daily by around 80% of the population 2. These results indicate that daily caffeine intake in the morning and afternoon hours does not strongly impair nighttime sleep structure nor subjective sleep quality in healthy good sleepers who regularly consume caffeine. Nevertheless, EEG power density in the sigma frequencies (12–16 Hz) during non-rapid eye movement sleep was reduced in both caffeine and withdrawal conditions when compared to placebo. Unexpectedly, neither polysomnography-derived total sleep time, sleep latency, sleep architecture nor subjective sleep quality differed among placebo, caffeine, and withdrawal conditions. Upon scheduled wake-up time, subjective sleep quality and caffeine withdrawal symptoms were assessed. After 9 days of continuous treatment, electroencephalographically (EEG)-derived sleep structure and intensity were recorded during a scheduled 8-h nighttime sleep episode starting 8 (caffeine condition) and 15 h (withdrawal condition) after the last caffeine intake. To address this question, we investigated the sleep of twenty male young habitual caffeine consumers during a double-blind, randomized, crossover study including three 10-day conditions: caffeine (3 × 150 mg caffeine daily), withdrawal (3 × 150 mg caffeine for 8 days, then switch to placebo), and placebo (3 × placebo daily). However, it is not clear whether these sleep disturbances disappear when caffeine is continuously consumed during daytime, which is common for most coffee drinkers. Acute caffeine intake can delay sleep initiation and reduce sleep intensity, particularly when consumed in the evening. ![]()
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